In the present study attempt was made to develop a simple, precise and economical spectrophotometric methods have been developed for the simultaneous estimation of atenolol and nifedipine in bulk and combined tablet dosage form. Both the drugs obey the Beer’s law in the concentration ranges employed10-16μg/ml for atenolol and 2-12μg/ml for nifedipine at λmax of 274nm and 238 nm. The methods were validated by following the analytical performance parameters suggested by the International Conference on Harmonization. All validation parameters were within the acceptable range. The developed methods were successfully applied to estimate the amount of atenolol and Nifedipine in bulk and combined tablet dosage forms. Recovery studies for atenolol and nifedipine are 99.58 and 99.50 in case of 120% recovery studies confirming the accuracy of the proposed method. The utility of the developed method has been successfully applied for the analysis of commercially available tablet dosage forms.
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